| 摘要 |
The present invention is a method of treating non-insulin-dependent diabetes mellitus comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of formula (I) for a period of time of more than 6 days: <IMAGE> (I) wherein Y is O R is OH, NHCONR4R5, or N=C(NR4R5)2; R4 and R5 are each independently selected from the group consisting of hydrogen; C1-10 alkyl, straight or branched chain; aryl C1-14 alkyl; and mono- or disubstituted aryl C1-4 alkyl where the substituents are fluoro, chloro, bromo, iodo or C1-10 alkyl, straight or branched chain; R1 and R2 are each independent selected from the group consisting of hydrogen, amino, and mono- or di-substituted amino where the substituents are C1-10 alkyl, straight or branched chain C3-8, cycloalkyl; provided that R1 and R2 may not both be amino or substituted amino; and R3 is hydrogen, trifluoromethyl; fluoro; chloro; bromo; or iodo; or a pharmaceutically acceptable salt thereof.
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