| 摘要 |
PCT No. PCT/SE96/00043 Sec. 371 Date Sep. 15, 1997 Sec. 102(e) Date Sep. 15, 1997 PCT Filed Jan. 18, 1996 PCT Pub. No. WO96/22299 PCT Pub. Date Jul. 25, 1996Method for the purification of a synthetic oligonucleotide from failure sequences comprising contacting a sample containing the desired oligonucleotide in protected water-soluble form with a hydrophilic adsorbent exhibiting anion exchange groups under conditions permitting binding of said oligonucleotide to said adsorbent, whereafter the adsorbed oligonucleotide is deprotected and separated from failure sequences. The characteristic feature of the method is to use an anion exchange adsorbent that binds the protected oligonucleotide under conditions of high as well as low ionic strength.
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