发明名称 |
Antisense oligonucleotide modulation of multidrug resistance-associated protein |
摘要 |
Compositions and methods are provided for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of the synthesis or metabolism of multidrug resistance-associated protein (MRP). In accordance with referred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding MRP. In a preferred embodiment, the oligonucleotide has at least one 2'-methoxyethoxy modification. Methods of preventing the development of multidrug resistance and of improving the efficacy of chemotherapy are also disclosed.
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申请公布号 |
US5801154(A) |
申请公布日期 |
1998.09.01 |
申请号 |
US19970835770 |
申请日期 |
1997.04.08 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
BARACCHINI, EDGARDO;BENNETT, C. FRANK;DEAN, NICHOLAS M. |
分类号 |
A61K38/00;C07H21/00;C12N15/113;(IPC1-7):C12N15/85;A61K48/00;C12Q1/68;C07H21/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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