发明名称 |
Polymeric contrast agents for medical imaging |
摘要 |
The invention provides polymeric polychelants containing polymer repeat units of formula [L-Ch-L-B] (where Ch is a polydentate chelant moiety; L is an amide or ester linkage; B is a hydrophobic group providing a carbon chain of at least 4 carbon atoms between the L linkages it interconnects) or a salt or chelate thereof, with the proviso that where Ch is 2,5-biscarboxymethyl-2,5-diazahex-1,6-diyl, the polychelant is metallated with lanthanide or manganese ions or B provides a carbon chain of at least 10 carbon atoms between the L linkages it interconnects and their salts and chelates. The paramagnetic polychelates of the polychelants of the invention have remarkably high R1 relaxivities.
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申请公布号 |
US5801228(A) |
申请公布日期 |
1998.09.01 |
申请号 |
US19950478803 |
申请日期 |
1995.06.07 |
申请人 |
NYCOMED IMAGING AS |
发明人 |
HOLLISTER, KENNETH ROBERT;KELLER, KENNETH EDMUND;WEI, DONG;PENG, XIN;LADD, DAVID LEE;HENRICHS, PAUL MARK;SNOW, ROBERT ALLEN |
分类号 |
C07D255/02;A61K41/00;A61K49/00;A61K49/08;A61K51/00;A61P39/02;C07D257/02;C07D259/00;C08G63/685;C08G69/48;(IPC1-7):C07F5/00;C09F13/00 |
主分类号 |
C07D255/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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