发明名称 |
MONOCLONAL ANTIBODY WHICH DISTINGUISHES HELPER INDUCER AND SUPPRESSOR INDUCER CD4+ LYMPHOCYTES |
摘要 |
A monoclonal antibody which binds preferentially to a subset of the human CD4+ l ymphocyte population whereby to positively and precisely distinguish between helper-inducer and supressor-induce r cells in the CD4+ cell population. The monoclonal antibody recognizes a novel antigen on the CD4+ lymphocytes by means of which it can bind CD4+ cells which express the antigen on the surface of CD4+ cells. The CD4+ subset cell population to whi ch this antibody preferentially binds is the CD4+ helper-inducer population. This selectivity of the monoclonal antibody enab les cell sorting, diagnostic and possible therapeutic applications thereof to be realized. The monoclonal antibody also re acts with CD8 cells, B cells and macrophages.
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申请公布号 |
CA2069501(C) |
申请公布日期 |
1998.09.01 |
申请号 |
CA19902069501 |
申请日期 |
1990.11.15 |
申请人 |
DANA-FARBER CANCER INSTITUTE |
发明人 |
SCHLOSSMAN, STUART F.;MORIMOTO, CHIKAO |
分类号 |
A61K39/395;A61K38/00;A61K49/00;C07K14/705;C07K16/00;C07K16/28;C07K19/00;C12N5/10;C12N5/20;C12N15/02;C12P21/08;C12R1/91;G01N33/53;G01N33/577;(IPC1-7):C12N5/18;A61K51/10;A61K47/48;G01N33/554 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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地址 |
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