| 摘要 |
<p>The invention refers to new 1-oxa-2-oxo-8-azaspiro(4,5)decane derivatives with the formula (I) where X means oxygen or a =NR group where R means hydrogen, C1-12-alkyl, C3-6-cycloalkyl, a carbocyclic C6-10-aryl or a carbocyclic C6-10-aryl-C1-4-alkyl group, both of the latter are substituted, at choice, on their aromatic part with one or several different halogens, one or several C1-4-alkyl or C1-4-alkoxy groups; both R1 and R2 represent a methylene group, or in the case X means the =NR group where R is as already defined, one of R1 and R2 may represent a hydroxy group and the other a methyl group; R3 means hydrogen or a phenyl group substituted, at choice, with one or several halogens, with one or several C1-4-alkyl or C1-4-alkoxy groups or hydroxy groups; R4 means hydrogen, one or several halogens, a C1-4-alkyl, C1-4-alkoxy, hydroxy or a trihalomethyl group; and n being 1, 2 or 3, as well as to their acid addition salts and quaternary ammonium salts. Further on, the invention refers to pharmaceutical preparations containing these compounds and to the procedure for their preparation. The compounds with the formula (I) exhibit inhibitory properties against calcium pick-up, antihypoxic and antianoxic properties as well as low toxicity. Thus, they are applicable to medical treatment of brain injuries of different origin.</p> |
