| 摘要 |
The invention relates to azacycloalkane derivativs having thegeneral formulawhere R1 & R2 are hydrogen atom, alkyl or phenyl radical and R1 &R2 together form oxoradical, R3 is hydrogen atom or alkyl radical,or R3 forms methylene radical, R4 is aromatic radical or when R3forms methylene radical R4 is a phenyl radical of which one carbonatom is bound to Y and another carbon atom adjacent to the firstone is bound to the methylene radical, R5 is either OR7 radicalwhere R7 is hydrogen atom, or benzyl radical, orN4-methylpiperazinyl radical, or NHR8-radical where R8 is hydroxygroup, methylpyridinyl or phenylmethyl radical, A is aromaticcycle optionally substituted, n has the value of 1 or 2, X is CH,0 or N, and Y is CH2, 0 or S. The invention also relates to amethod for the preparation of compounds and their application intherapy.20 claims
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