| 摘要 |
PCT No. PCT/GB91/00587 Sec. 371 Date Oct. 14, 1992 Sec. 102(e) Date Oct. 14, 1992 PCT Filed Apr. 15, 1991 PCT Pub. No. WO91/16306 PCT Pub. Date Oct. 31, 1991.There is disclosed a process for the preparation of a compound of structure (I) <IMAGE> (I) in which n is 1 to 3 and each group R is hydrogen or C1-4 alkyl, which comprises, reaction of compound of structure (II) <IMAGE> (II) (prepared by esterifying the hydroxyl compound) in which R1 is C1-4alkyl, phenyl or substituted phenyl and n is 1 to 3, with an amine HNR2 in which R is as described for structure (I), and optionally thereafter forming a salt. Intermediates are also disclosed. |
