| 摘要 |
1. New morpholine compounds - antagonists of tachykinine receptor - with the general formula I: IMAGE> and their pharmaceutically acceptable salts, while: R1 is selected from the following group: (1) atom of hydrogen; (2) C1-6alkyl, non-substituted or substituted with one or several substituents, selected from the following group: (a) hydroxyl, (b) oxo, (c) C1-6alkoxyl, (d) phenyl-C1-3alkoxyl, (e) phenyl, (f) -CN, (g) atom of a halogen,(h) -NR9>R10>, where R9> and R10> are selected independently from the following group: (i) atom of hydrogen, (ii) C1-6alkyl, (iii) hydroxy-C1-6alkyl and (iv) phenyl, (i) -NR9>COR10>, where R9> and R10> are defined above, (j) -NRm9>CO2R10>, where R9> and R10> are defined above, (k) -CONR9>R10>, where R9> and R10> are defined above, (l) -COR9>, where R9> is defined above, (m) -CO2R9>, where R9> is defined above, (n) a heterocyclic group, while the heterocyclic group is selected from the following group of compounds:...
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