发明名称 |
PROCESS FOR PRODUCING PROTEINASE INHIBITORS |
摘要 |
The invention comprises peptide variants based on the domains with inhibitory activity of human bicunin (i.e. the component with inhibitory activity of inter- alpha -trypsin inhibitor, or the acid-stable serum trypsin inhibitor, or the urinary trypsin inhibitor), methods for the preparation of these peptide variants with the aid of genetic engineering methods with microorganisms (bacteria, lower eukaryotes), and pharmaceutical compositions containing these peptide variants. The peptide variants are characterised by their ability to inhibit serine proteases, e.g. pancreatic and granulocytic elastase, cathepsin G or plasma kallikrein. |
申请公布号 |
HU214985(B) |
申请公布日期 |
1998.08.28 |
申请号 |
HU19900003010 |
申请日期 |
1990.05.11 |
申请人 |
BAYER AG. |
发明人 |
DAS,RATHINDRA;FRITZ,HANS;GEBHARD,WOLFGANG |
分类号 |
C12N15/09;A61K38/00;A61K38/55;A61P1/16;A61P7/00;A61P7/02;A61P7/04;A61P9/00;A61P11/00;A61P13/02;A61P13/12;A61P15/00;A61P17/00;A61P29/00;A61P43/00;C07K14/00;C07K14/47;C07K14/81;C12N9/99;C12N15/15;C12P21/02;C12R1/19;C12R1/865 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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