发明名称 |
PROCESS FOR PRODUCING OF ISOHIRUDINE WITH IMPROVED STABILITY |
摘要 |
Novel synthetic isohirudins with improved stability The invention relates to novel synthetic isohirudins which have improved stability owing to exchange in the region of the Asp-Gly motif. This results, on the one hand, in an increase in the yield during workup and, on the other hand, in making possible pharmaceutical formulation as directly injectable solution ready for use. |
申请公布号 |
HU214701(B) |
申请公布日期 |
1998.08.28 |
申请号 |
HU19920003838 |
申请日期 |
1992.12.04 |
申请人 |
HOECHST AG. |
发明人 |
CRAUSE,PETER;HABERMANN,PAUL;SCHMID,GERHARD;TRIPIER,DOMINIQUE;ULMER,WOLFGANG |
分类号 |
A61K38/55;A61K38/00;A61P7/02;C07K1/14;C07K14/00;C07K14/815;C12N15/09;C12N15/12;C12P21/02;C12R1/19 |
主分类号 |
A61K38/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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