发明名称 |
METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING CHRONOLOGICAL AGING IN HUMAN SKIN |
摘要 |
The deleterious effects of the passage of time on human skin (i.e., chronological aging of human skin) can be prevented and treated with the topical application of a retinoid, preferably retinol. We have found that some of the same pathways (namely the stress-activated pathways, SAPs) activated in photoaging of human skin (i.e., sun-induced premature skin aging) are similarly elevated in the skin of elderly people. We have also found that other pathways (namely the mitogen-activated ERK pathway) is depressed in the same skin. Treatment of chronologically-aged skin with a retinoid both inhibits degradation of dermal collagen and promotes procollagen synthesis. Biopsied sections from skin of elderly (80+ years old) show that a single treatment can increase epidermal thickness, improve the dermal collagen density, and promote the formation of rete pegs and dermal papillae (see Fig. 13), and can decrease the amount of c-Jun and increase the amounts of Types I and III procollagen (see Fig. 18). Such benefits are also helpful in preventing bruising, tearing, and ulceration of elderly skin. |
申请公布号 |
WO9836742(A1) |
申请公布日期 |
1998.08.27 |
申请号 |
WO1998US03743 |
申请日期 |
1998.02.23 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
VARANI, JAMES;FISHER, GARY, J.;VOORHEES, JOHN, J.;KANG, SEWON |
分类号 |
A61K45/00;A61K8/37;A61K8/42;A61K8/44;A61K8/63;A61K8/67;A61K31/07;A61K31/11;A61K31/16;A61K31/185;A61K31/19;A61K31/20;A61K31/203;A61K31/59;A61K31/60;A61K31/65;A61P17/00;A61P43/00;A61Q19/08 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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