CONTROL OF IL4 PRODUCTION AS A THERAPEUTIC REGULATOR OF IMMUNE FUNCTION

摘要

Therapeutic compositions that include small molecule affectors of CP2 function, particularly inhibitors or activators of CP2 production or of complex formation between CP2 and a CP2 recognition element in the IL4 promoter; methods of screening for such affectors of CP2 function; and methods of use of such compositions are disclosed. The inhibitors or activators are useful as therapeutic agents in methods of treatment of immunological disorders, to restore appropriate immunological balance. Also disclosed are methods of treatment using gene therapy, such as using CP2 cDNA to transform cells from Th1 to Th2, to decrease a harmful inflammatory response in a patient, or using CP2 dominant negative cDNA to transform cells from Th2 to Th1, in order to induce an inflammatory response.