| 摘要 |
FIELD: organic chemistry, antibiotics. SUBSTANCE: invention relates to an anthracycline glycoside of the general formula (I) <EMI ID=0.474 HE=54 WI=48 TI=CHI> where R<SB>1</SB> - hydrogen or methoxy-group; R<SB>2</SB> - hydrogen or hydroxy-group; A and B - both hydrogen or one of A and B - hydrogen and other - hydroxy-group or group of the formula OSO<SB>2</SB>P<SB>5</SB> where R<SB>5</SB> - C<SB>1</SB>-C<SB>4</SB>-alkyl arbitrarily substituted with C<SB>1</SB>-C<SB>4</SB>-alkyl, nitro-, amino-, methoxy-group or halogen; R<SB>3</SB> - hydrogen atom or group of the formula (2) and R<SB>4</SB> - group of the formula (2): (CH<SB>2</SB>)<SB>n</SB>-X where n = 2 or 3; X - hydroxy-group, halogen or group of the formula OSO<SB>2</SB>P<SB>5</SB> where R<SB>5</SB> - as indicated above at condition that if R<SB>2</SB>, X and A - hydroxy-group and R<SB>3</SB> - H then n must be 3, or its pharmaceutically acceptable salt. Synthesized compounds show antitumor activity. Invention proposes methods of their synthesis and pharmaceutical composition based on thereof. EFFECT: improved method of synthesis, enhanced effectiveness of compounds synthesized. 8 cl, 17 tbl, 7 ex-
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