| 摘要 |
<p>The method for determining the phenotype of a haptoglobin in a biological fluid, characterized in that it comprises the steps of (a) contacting the biological fluid with a haptoglobin binding partner, in particular with Streptococcus pyogenes, which has at least two locations by which it can bind to haptoglobin so as to be able to agglutinate haptoglobins and/or to be agglutinated thereby to different degrees, depending on the haptoglobin phenotype; (b) measuring the degree of agglutination; and (c) determining, based on the degree of agglutination, the phenotype of the haptoglobin in the biological fluid. The kit comprises the haptoglobin binding partner and optionally a reference haptoglobin sample. This kit and method can be used for estimating a patient's prognosis following viral infection, for determining graft survival following liver transplantation, and for improving the interpretation of different laboratory parameters. Compared to existing assays, they enable a quick determination of the haptoglobin phenotype.</p> |
