Verfahren zur Herstellung von enantiomerenreinen Alkoholen

摘要

The invention relates to a method for producing enantiomer-free alcohols of formula (I) (Ia or Ib), in which the substituents represent the following; R<1> represents hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, or C1-C6-alkanoyl-; R<2> and R<3> independently of each other represent hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, or C1-C6-alkanoyl-, C1-C6-alkylthio-, C1-C6-alkyl sulfinyl- or C1-C6-alkyl sulfonyl-; and R<4> is a substituted or unsubstituted C1-C6-alkyl-, C3-C6-cycloalkyl-. Said method is characterized in that compounds of formula (II), in which the substituents R<1> to R<4> have the meaning given above, are reduced to compounds of formula (I) in an aqueous solution, in the presence of a carbon source and a microorganism or a reducing agent and an enzyme.