| 摘要 |
PCT No. PCT/GB98/00322 Sec. 371 Date Jul. 20, 1999 Sec. 102(e) Date Jul. 20, 1999 PCT Filed Feb. 2, 1998 PCT Pub. No. WO98/34923 PCT Pub. Date Aug. 13, 1998The present patent application discloses compounds having formula (I) or a pharmaceutically acceptable salt thereof or an oxide thereof, wherein R3 is (II), wherein A, B and D each is CH, or one or two of A, B and D is N and the others are CH; R11 is phenyl, benzimidazolyl, or monocyclic heteroaryl all of which may be substituted one or more times with substituents selected from alkyl, alkoxy, phenyl, halogen, CF3, amino, nitro, cyano, acyl, acylamino, phenyl and monocyclic heteroaryl; and one of R6 and R7 is hydrogen and the other is furanyl or isoxazolyl each of which may be substituted one or more times with substituents selected from halogen, alkyl, alkoxy and phenyl. The compounds are useful for the treatment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders. |
