Nucleotide analogs

摘要

PCT No. PCT/US94/10539 Sec. 371 Date May 6, 1996 Sec. 102(e) Date May 6, 1996 PCT Filed Sep. 16, 1994 PCT Pub. No. WO95/07920 PCT Pub. Date Mar. 23, 1995Nucleotide analogs characterized by the presence of an amidate lirked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolysed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for the synthesis and use are described.