| 摘要 |
HCAR and MCAR protein molecules are human and mouse proteins (respectively) that serve as cellular receptors for adenoviruses of the serotypes 2 and 5 (subgroup C) and for the group B coxsackieviruses. The invention provides DNA molecules encoding these proteins or encoding functional derivatives thereof, host cells transformed with the DNA molecules and methods of producing the recombinant proteins or derivatives. These proteins, peptide fragments of these proteins which correspond to their extracellular domains, as well as other functional derivatives, in particular oligopeptides which bind virus are also provided. Isolated HCAR or MCAR proteins or fragments or variants thereof are used to prevent or treat virus infections. Expressing the above DNA in cells which lack these viral receptors renders the cells susceptible to transformation by adenoviral vectors carrying genes for gene therapy. |
