Inhibitors of farnesyl protein transferase

摘要

This invention relates to compounds which inhibit a farnesyltransferase and RAS protein farnesylation; it makes them suitable for use as agents against cancer. These compounds are also suitable for treatment of non cancerous diseases related to a signal transmission proceeding through RAS and diseases related with other proteins than RAS, which are also modified after the translation by the farnesyltransferase ferment. Compounds may also act as inhibitors of other prenyl transferase and therefore they may be effective for treating diseases related to other prenyl modifications of proteins.