This invention is directed to mutant SPE-A toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-A toxin has at least one amino acid change and is substantially non-lethal compared with the wild type SPE-A toxin. The mutant SPE-A toxins can form vaccine compositions useful to protect animals against the biological activities of wild type SPE-A toxin.
申请公布号
WO9824911(A3)
申请公布日期
1998.08.20
申请号
WO1997US22228
申请日期
1997.12.05
申请人
REGENTS OF THE UNIVERSITY OF MINNESOTA;SCHLIEVERT, PATRICK, M.;ROGGIANI, MANUELA;STOEHR, JENNIFER;OHLENDORF, DOUGLAS
发明人
SCHLIEVERT, PATRICK, M.;ROGGIANI, MANUELA;STOEHR, JENNIFER;OHLENDORF, DOUGLAS