PEPTIDE MODULATION OF REPERFUSION INJURY

摘要

An in vivo method of reducing reperfusion injury in a mammal resulting from reperfusion of a temporarily occluded blood vessel which comprises the steps of administering into the mammal's bloodstream an effective amount of a proline/arginine rich peptide such as PR-39 (SEQ ID NO: 1). The method has particular application in surgical procedures such as coronary bypass and organ transplantation surgery and where reperfusions occur subsequent to a spontaneous occlusion. Preferred peptides have up to about 50 amino acid residues with a a plurality of -PXXP- sequences.