Novel optically active isomers of prostaglandin analoguesof natural configuration useful as hypotensive agents, diuretics,contraceptives, for treating gastric ulcer and asthma, and forinhibiting platelet aggregation

摘要

Optically active isomers of prostaglandin analogues of natural configuration are new. Optically active isomers ofprostaglandin analogues of natural configuration of formula (1-6), are new. X 1= group of formulae (a-g). Independent claims are included for the following: (1) process for preparation of optically active isomers of prostaglandin analogues of natural configuration (1), and their esters, salts, alcohol derivatives and dihydro-prostaglandin (PG1) derivatives; (2) optically active isomer of prostaglandin analogue of natural (3) configuration of formula (8); and (4) optically active isomer of prostaglandin analogue of natural configuration of formula (9). THP : 2-tetrahydropyranyl;and X 2group of formulae (a1-g1). [Image] [Image] [Image] [Image] ACTIVITY : Hypotensive; Diuretic; Thrombolytic; Antiulcer; Gastrointestinal-Gen.; Antiasthmatic; Anticoagulant. In a test for measuring anti-hypertensive activity using allobarbital anaesthetized dog, prostaglandin analogue e.g. 16-ethyl-prostaglandin-E2 exhibited hypotensive degree of 200. MECHANISM OF ACTION : None given.