发明名称 |
GENE THERAPY FOR ALLEVIATING ERECTILE DYSFUNCTION |
摘要 |
The present invention is directed towards gene therapy for erectile dysfunction through delivery and expression of a recombinant vector containing a DNA sequence encoding a protein involved in the regulation of smooth muscle tone into a smooth muscle cell. Also provided by the present invention is a method of inducing penile erection in a subject comprising the introduction and expression of a DNA sequence encoding a protein involved in the regulation of smooth muscle tone into a sufficient number of cells of the subject to induce penile erection in the subject. The present invention also provides a recombinant vector comprising the DNA of or corresponding to at least a portion of the genome of a virus, which portion is capable of directing the expression of a DNA sequence, and DNA encoding a protein involved in the regulation of smooth muscle tone operably linked to the viral DNA and capable of being expressed as a functional gene product in the target cell. Also provided by the present invention is a smooth muscle cell which expresses a gene encoding a protein involved in the regulation of smooth muscle tone.
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申请公布号 |
CA2280770(A1) |
申请公布日期 |
1998.08.20 |
申请号 |
CA19982280770 |
申请日期 |
1998.02.05 |
申请人 |
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY |
发明人 |
GELIEBTER, JAN;MELMAN, ARNOLD;CHRIST, GEORGE J.;REHMAN, JAMIL |
分类号 |
C12N15/09;A61K35/76;A61K38/00;A61K38/17;A61K38/43;A61K38/44;A61K38/45;A61K38/51;A61K48/00;A61P15/10;C12N5/10;(IPC1-7):C12N9/12;C12N15/00;C07H21/02;A01N43/04 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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