| 发明名称 |
COMPOSITIONS FOR THE INHIBITION OF BONE RESORPTION |
| 摘要 |
The disclosed invention is based on the observation that functional NMDA receptors are present on osteoclasts. Use of NMDA antagonists to inhibit bone resorption is disclosed, useful therefore in the treatment of bone disorders such as osteoporosis and Paget's disease. The NMDA antagonists used were Phencyclidine and Dizocilpine.
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| 申请公布号 |
WO9835674(A1) |
申请公布日期 |
1998.08.20 |
| 申请号 |
WO1998GB00443 |
申请日期 |
1998.02.12 |
| 申请人 |
SMITH & NEPHEW PLC;SKERRY, TIMOTHY, MICHAEL;SUVA, LARRY, JOHN |
发明人 |
SKERRY, TIMOTHY, MICHAEL;SUVA, LARRY, JOHN |
| 分类号 |
C07D215/22;A61K31/191;A61K31/194;A61K31/404;A61K31/445;A61K31/451;A61K31/46;A61K31/4704;A61K31/498;A61K31/4985;A61K31/5025;A61K31/529;A61K31/662;A61K31/7105;A61K39/395;A61K45/00;A61K48/00;A61P3/14;A61P19/08;A61P19/10;C07D211/14;C07D241/42;C07D241/44;C07D471/04;C07D471/08;C07D487/04;C07D487/06;(IPC1-7):A61K31/445 |
主分类号 |
C07D215/22 |
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