| 摘要 |
<p>Disclosed is a modified extracellular domain of a cytokine receptor protein, capable of being crystallized without being complexed to a ligand molecule. The receptor preferably is a homo- or heterodimeric cytokine receptor, having at least one molecule segment which contributes to a disordered structure deleted. The most preferred receptor is human growth hormone receptor (hGHR). Also disclosed are crystals of unliganded modified receptor suitable for binding studies with ligand candidates, a method of obtaining the crystals, as well as a method of designing drugs with cytokine receptor activity by employing such crystals according in binding studies with selected ligand candidates.</p> |
