PROCESS FOR PREPARING O-ACETYLSERINE, L-CYSTEINE AND L-CYSTEINE-RELATED PRODUCTS

摘要

A process is for preparing O-acetylserine, L-cysteine and sulphurous compounds derived therefrom using feedback-resistant serine acetyl transferases. In comparison with the wild-type enzyme, these serine acetyl transferases have reduced sensitivity to the inhibitor L-cysteine and a protein sequence which, in comparison with the wild-type enzyme, displays at least one mutation or deletion. The process has a mutation which lies in the sequence region of the amino acid in position 97 up to and including the amino acid in position 273 or the deletion lies in the carboxy terminal sequence region as from the amino acid in position 227, position 1 being the starter methionine of FIG. 5 (SEQ ID NO:1) and the mutation from Met to Ile in position 256 being excluded.