发明名称 |
Taxane compounds and uses thereof |
摘要 |
<p>Taxane derivatives modified at 6 - 7 positions of the taxane derivative skeleton (taxol numbering) of formula Ia: <IMAGE> wherein R1 represents OR or R wherein R is C1-C5 alkyl, C2-C5 alkenyl or C6-C10 aryl and R2 represents H or CH3CO, are endowed with antitumor activity. The compounds of formula Ia and their epimers at 2'position are prepared from a compound of formula II <IMAGE> wherein R3 is a leaving group and R4 is a hydroxy protecting group. Compounds of formula II are novel when R3 is CH3SO2O or CF3SO2O in the alpha-configuration and also have antitumour activity.</p> |
申请公布号 |
GB2289277(B) |
申请公布日期 |
1998.08.19 |
申请号 |
GB19950009353 |
申请日期 |
1995.05.09 |
申请人 |
* PHARMACIA SPA |
发明人 |
NICOLA * MONGELLI;MARIA * MENICHINCHERI;DOMENICO * FUSAR BASSINI;MARINA * CIOMEI |
分类号 |
A61K31/335;A61K31/337;A61P35/00;C07D305/14;(IPC1-7):C07D305/14 |
主分类号 |
A61K31/335 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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