Acylphenylglycine derivative and preventive and remedy for diseases caused by increased collagenase activity containing said compound as active ingredient

摘要

PCT No. PCT/JP94/01284 Sec. 371 Date Feb. 8, 1996 Sec. 102(e) Date Feb. 8, 1996 PCT Filed Aug. 3, 1994 PCT Pub. No. WO95/04715 PCT Pub. Date Feb. 16, 1995An acylphenylglycine derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, and a preventive and remedy for diseases caused by an increased collagenase activity containing the same as the active ingredient, wherein R1 represents hydrogen atom, methyl, methylaminomethyl or morpholinomethyl; R2 represents hydrogen atom, hydroxy, fluorine atom, or C1-C4 linear or branched alkyl; and R3 represents C1-C4 linear or branched alkyl. The compound (I) and the salt maintains a potent collagenase inhibitor activity in the blood for long after being administered, and are useful as a remedy for various diseases believed to be caused by an increased collagenase activity. <IMAGE> (I)