| 摘要 |
PCT No. PCT/EP95/03383 Sec. 371 Date Feb. 28, 1997 Sec. 102(e) Date Feb. 28, 1997 PCT Filed Aug. 26, 1995 PCT Pub. No. WO96/06832 PCT Pub. Date Mar. 7, 1996The invention concerns new 4-aminopyridazines of the general formula I <IMAGE> (I) in which R1 denotes an R2-SO2-O- or R2-SO2-NR3- group in which R2 denotes a cycloalkyl residue, an unsubstituted or substituted aryl or heteroaryl residue, R3 denotes a hydrogen atom, an alkyl or alkyloxyalkyl group which can be unsubstituted or substituted once or several times by hydroxy groups wherein the hydroxy groups can be substituted by alkyl, hydroxyalkyl, alkyloxyalkyl, hydroxyalkyloxyalkyl or alkylcarbonyl groups and wherein in each case two vicinal hydroxy groups can be linked together by alkylidene groups, as well as hydrates, solvates and physiologically tolerated salts thereof. The invention also concerns the optically active forms, racemates and mixtures of diastereomers of these compounds, processes for their production and pharmaceutical agents containing these compounds having a thrombin-inhibiting action.
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