发明名称 |
Liposomal antineoplastic agent compositions |
摘要 |
A method for encapsulation of antineoplastic agents in liposomes is provided, having preferably a high drug:lipid ratio. Liposomes may be made by a process that loads the drug by an active mechanism using a transmembrane ion gradient, preferably a tranamembrane pH gradient. Using this technique, trapping efficiencies approach 100%, and liposomes may be loaded with drug immediately prior to use, eliminating stability problem related to drug retention in the liposomes. Drug:lipid ratios employed are about 3-80 fold higher than for traditional liposome preparations, and the release rate of the drug from the liposomes is reduced. An assay method to determine free antineoplastic agents in a liposome preparation is also disclosed.
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申请公布号 |
US5795589(A) |
申请公布日期 |
1998.08.18 |
申请号 |
US19970794988 |
申请日期 |
1997.02.05 |
申请人 |
THE LIPOSOME COMPANY, INC. |
发明人 |
MAYER, LAWRENCE D.;BALLY, MARCEL B.;CULLIS, PIETER R.;GINSBERG, RICHARD S.;MITILENES, GEORGE N. |
分类号 |
A61K9/127;A61K9/133;(IPC1-7):A61K9/127 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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