Radioiodinated phospholipid ether analogues

摘要

Novel radioiodinated analogues of naturally-occurring phospholipid ethers are tumor-specific and have a triglycerol backbone structure which, in certain embodiments, is substituted at the 3-position with an alkyl phosphocholine and include a monoiodinated benzoyl side chain substituted at the 2-position in accordance with the general formula: <IMAGE> where n=1-15 <IMAGE> <IMAGE> M=0-15; Z=123I, 125I, and 131I; Y=NH2, NR2, and NR3, and R=alkyl, aralkyl.