| 摘要 |
1,170,692. 1,2,3,4 - Tetrahydronaphthalene compounds. SHIONOGI & CO. Ltd. 5 July, 1967 [9 July, 1966], No. 30949/67. Heading C2C. The invention comprises novel compounds A of the formula in which R 1 is hydrogen or C 1-7 hydrocarbyl, R 2 , R 3 , R 4 and R 5 are each hydrogen, C 1-7 hydrocarbyl, hydroxy, C 1-7 alkoxy or halogen and R 7 is C 1-3 alkyl, and a process for preparing compounds of formula by oxidizing a dihydronaphthalene compound of formula with a percarboxylic acid in a reaction medium containing 50-70% by volume of an alkanol R 7 OH at - 30‹ to + 10‹ C. to give one of the above compounds A, which is then heated at 50-200‹ C. in the presence of an acid catalyst. The cis- and trans-isomers of 1-methyl-1,6- dimethoxy - 2 - hydroxy - 1,2,3,4 - tetrahydronaphthalene are separated by crystallization and chromotography and converted to their pnitrobenzoates. Some of the above 2-tetralones are converted to their semicarbazones from which the ketones may be regenerated by acid hydrolysis. Reference has been directed by the Comptroller to Specifications 1,119,069 and 1,119,070. |
