MICROGRANULES CONTENANT DU CISPLATINE, PROCEDE DE FABRICATION, PREPARATION PHARMACEUTIQUE ET UTILISATION EN POLYCHIMIOTHERAPIE OU EN ASSOCIATION AVEC UNE RADIOTHERAPIE

摘要

The invention concerns a novel formulation of cisplatin, for oral administration, in the form of microgranules with controlled release, and its method of preparation by grossing in an aqueous medium. The invention also concerns a pharmaceutical preparation containing cisplatin microgranules with controlled release and anticancer agent as combination product to be used simultaneously, separately or at different times in anticancer therapy, and the use of said microgranules for making medicine to be orally administered for use in polychemotherapy or in combination with radiotherapy.