The present invention relates to a novel DCDGF protein which is a member of a novel family of growth factors of which the prototype is called Insect-Derived Growth Factor (IDGF). In particular, isolated nucleic acid molecules are provided encoding the human DCDGF protein. DCDGF polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DCDGF activity. Also provided are diagnostic methods for diagnosing DiGeorge Syndrome and, particularly, immune system-related disorders and therapeutic methods for treating immune system-related disorders.
申请公布号
WO9835039(A1)
申请公布日期
1998.08.13
申请号
WO1998US02329
申请日期
1998.02.05
申请人
HUMAN GENOME SCIENCES, INC.;FAN, PING;SOPPET, DANIEL, R.;LI, YI;DILLON, PATRICK, J.
发明人
FAN, PING;SOPPET, DANIEL, R.;LI, YI;DILLON, PATRICK, J.