| 摘要 |
This invention provides a method and apparatus for disrupting the outermost layer of the skin, the stratum corneum, to provide access to biological fluid, which can be used to determine the concentration of glucose in blood. The invention can be used to extract interstitial fluid, blood and mixtures of interstitial fluid and blood from the body of a human or an animal. The method comprises the steps of 1) attaching a receptacle (26) for collecting biological fluid to the surface of the skin of a patient, 2) introducing an oscillation concentrator (20) attached to an oscillation element (12) into the receptacle (26), 3) positioning the oscillation concentrator (20) at a desired distance from the surface of the skin, 4) activating the oscillation element (12) to transversely oscillate the attached oscillation concentrator (20), 5) collecting the biological fluid after a specific period of time, and 6) analyzing the biological fluid for the presence of an analyte. |
