Novel combination of preservatives (methyl and propyl parabens, benzyl alcohol, and 2-phenoxyethanol) were found to pass antimicrobial testing according to USP, BP, and EP. The new preservatives were put into vaccines using L-histidine as a buffer to keep pH at 7.0. HPLC methods were developed to analyze these preservatives and their degradation products.
申请公布号
WO9834594(A1)
申请公布日期
1998.08.13
申请号
WO1998US02283
申请日期
1998.02.03
申请人
MERCK & CO., INC.;NG, ASSUNTA, S.;HENNESSEY, JOHN, P.;MANCINELLI, RALPH, J.
发明人
NG, ASSUNTA, S.;HENNESSEY, JOHN, P.;MANCINELLI, RALPH, J.