发明名称 |
PROCESS FOR THE PREPARATION OF IODINATED CONTRAST AGENTS AND INTERMEDIATES THEREFOR |
摘要 |
The invention provides a process for the production of a 2,3-dihydroxypropylamino compound, said process comprising the reaction steps of: (i) obtaining an allylamino compound; (ii) epoxidizing said allylamino compound to yield an epoxypropylamino compound; and (iii) hydrolysing said epoxypropylamino compound to yield a 2,3-dihydroxypropylamino compound. This process may be used to produce simple 2,3-dihydroxypropylamino compounds such as APD or complex ones such as BAPD (an intermediate in the production of iohexol).
|
申请公布号 |
WO9834905(A1) |
申请公布日期 |
1998.08.13 |
申请号 |
WO1998GB00356 |
申请日期 |
1998.02.05 |
申请人 |
NYCOMED IMAGING AS;COCKBAIN, JULIAN;LANE, DAVID, REDICK;VASILEVSKIS, JANIS |
发明人 |
LANE, DAVID, REDICK;VASILEVSKIS, JANIS |
分类号 |
A61K49/04;C07C213/00;C07C213/04;C07C215/00;C07C231/02;C07C231/12;C07C231/14;C07C233/05;C07C233/18;C07C233/22;C07C233/65;C07C233/69;C07C233/91;C07C237/30;C07C237/42;C07C237/46;(IPC1-7):C07C213/04;C07D303/36 |
主分类号 |
A61K49/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|