Inhibition of IgE-mediated allergies by a human IgE-derived oligopeptide

摘要

Peptides are disclosed that are capable of effective recognition of the human IgE Fc epsilon receptor. The peptides partially comprises a fragment of human IgE. By addition of constraining amino acid residues at or near the polypeptides' N- and C-termini, these peptides may be forced to assume a loop configuration. These constrained peptides are useful as competitors of human IgE for the Fc epsilon receptor, and may be used to block the development of type I hypersensitivity.