发明名称 |
METHOD FOR THE PREPARATION OF CITALOPRAM |
摘要 |
A method for the preparation of citalopram is described comprising reaction of a compound of Formula (IV) wherein R<1> is H or C1-6alkylcarbonyl successively with a Grignard reagent of 4-halogen-fluorophenyl and a Grignard reagent of 3-halogen-N,N-dimethylpropylamine, effecting ring closure of the resulting compound of Formula (VI) and converting the resulting 1,3-dihydroisobenzofuran compound to the corresponding 5-cyano derivative, i.e. citalopram. 00000 |
申请公布号 |
WO9819512(A3) |
申请公布日期 |
1998.08.13 |
申请号 |
WO1997DK00513 |
申请日期 |
1997.11.11 |
申请人 |
H. LUNDBECK A/S;PETERSEN, HANS;BREGNEDAL, PETER;BOEGESOE, KLAUS, PETER |
发明人 |
PETERSEN, HANS;BREGNEDAL, PETER;BOEGESOE, KLAUS, PETER |
分类号 |
A61K31/34;A61K31/343;A61P25/24;C07C215/68;C07C225/22;C07C233/33;C07C233/43;C07D307/87;C07D307/88 |
主分类号 |
A61K31/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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