发明名称 |
Assay for measuring the degradation of type I collagen |
摘要 |
<p>An antibody raised to type I collagen carboxyterminal cross-linked telopeptide isolated from decalcified human or animal bone, may be used in an assay to determine the concentration of liberated carboxyterminal telopeptide region of the type I collagen molecule in a sample. When the sample is a body fluid such as serum or urine the degradation product measured is resistant to further degradation, since it contains a multivalent intermolecular cross-link, and can thus be found in the body fluid. The assay may be used to assess the degradation of type I collagen, the major organic constituent of bone matrix.</p> |
申请公布号 |
EP0505210(B1) |
申请公布日期 |
1998.08.12 |
申请号 |
EP19920302446 |
申请日期 |
1992.03.20 |
申请人 |
ORION-YHTYMAE OY |
发明人 |
RISTELI, JUHA;RISTELI, LEILA |
分类号 |
C07K14/435;C07K1/20;C07K16/00;C07K16/18;G01N33/53;G01N33/577;G01N33/68;(IPC1-7):G01N33/68 |
主分类号 |
C07K14/435 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|