Process for the preparation of substituted N-(aryl)-1,2,4-triazolopyrimidine-2-sulfonamides

摘要

The preparation of N-(aryl)-1,2,4-triazolopyrimidine-2-sulfonamides of formula (V) by the coupling of substituted 1,2,4-triazolopyrimidine-2-sulfonyl halides of formula (VI) with aryl amines of substantially reduced nucleophilic reactivity is facilitated by conducting the reaction in the presence of a pyridine base and a catalytic amount of dimethyl sulfoxide.