发明名称 |
Improvements in or relating to contrast agents |
摘要 |
Proteinaceous gas- or gas precursor-containing microbubble contrast agents, e.g. for use in ultrasound and/or MR imaging, in which the protein matrix is crosslinked by reaction with a bifunctional aldehyde (e.g. a dialdehyde such as glutaraldehyde or an alpha , beta -unsaturated aldehyde such as acrolein) in an aqueous medium at substantially neutral pH exhibit improved in vivo and storage stabilities, particularly if the matrix is also reacted with a Schiff's base reducing agent such as a borohydride. Modification of the size distribution of such crosslinked proteinaceous gas-containing contrast agents, e.g. to reduce the mean size of the microbubbles, further enhances their stability and permits preparation of novel contrast agents having a particularly narrow microbubble size distribution. |
申请公布号 |
EP0835664(A3) |
申请公布日期 |
1998.08.12 |
申请号 |
EP19970203948 |
申请日期 |
1993.09.03 |
申请人 |
NYCOMED AS |
发明人 |
KLAVENESS, JO;RONGVED, PAL;JOHANSEN, JOHN HENDRIK;FOSS, PER ANTONIUS;HOGSET, ANDERS;HVOSLEF, ANNE MARIE |
分类号 |
A61K49/00;A61K49/18;A61K49/22 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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