发明名称 |
NOVEL ADHERENCE FACTORS OF NON PATHOGENIC MICROORGANISMS AND APPLICATIONS THEREOF FOR SCREENING MIROORGANISMS FOR SPECIFIC PROBIOTIC PROPERTIES; NOVEL PHARMACEUTICAL COMPOSITIONS AND FOOD ADDITIVES COMPRISING SUCH MICROORGANISMS AND ADHERENCE FACTORS |
摘要 |
A protein obtainable from a non pathogenic microorganism, said protein having mucosa binding promoting activity and a molecular weight of 20-40 kD is disclosed. Application of such a protein or a peptide derived therefrom in a method of screening non pathogenic microorganisms for a microorganism capable of specifically binding mucosa, said method comprising detection in a manner known per se of the presence of a particular protein on or in a microorganism or in a culture of microorganisms, said particular protein being the already defined protein. Kits suitable for such a screening method are also disclosed. Use of a component selected from the group of components comprising a protein or peptide as defined; an expression vector comprising nucleic acid encoding such protein or peptide; a recombinant microorganism or a part of said microorganism expressing such protein or peptide, said part expressing mucosa binding promoting activity; a non pathogenic microorganism capable of expressing such protein or peptide or a part of said microorganism, said part expressing mucosa binding promoting activity as pharmaceutically active component in a pharmaceutical composition for prophylaxis and/or treatment of disease or illness associated with a mucosa colonising pathogenic microorganism. Use of such components as food additive and compositions comprising such components are described. |
申请公布号 |
EP0857213(A1) |
申请公布日期 |
1998.08.12 |
申请号 |
EP19960933659 |
申请日期 |
1996.10.21 |
申请人 |
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO |
发明人 |
LEER, ROBERT, JAN;POUWELS, PIETER, HENDRIK;CONWAY, PATRICIA, LYNNE |
分类号 |
A23L3/3526;A23L29/00;A61K31/00;A61K35/66;A61K38/00;A61K48/00;A61P31/00;A61P31/04;C07K14/205;C07K14/285;C07K14/335;C07K14/35;C07K16/12;C07K19/00;C12N1/21;C12N15/09;C12N15/31;C12P21/02;C12P21/08;C12Q1/68;G01N33/53;G01N33/569 |
主分类号 |
A23L3/3526 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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