CRYSTALLISATION OF PROTEINS

摘要

A method of providing zinc containing crystals of a protein derivative which has a lysine residue which carries a lipophilic substituent on the epsilon -amino group, said method comprising: a) providing a solution of the protein derivative in an alkaline buffer, which further contains a zinc salt; b) adjusting the pH value of the solution to a value between 7 and 10 and c) isolating the crystals formed.