TARGETED MODIFICATION OF THE CCR-5 GENE

摘要

Modified oligonucleotides, capable of forming triple-stranded complexes with the CCR-5 chemokine receptor gene, are provided. The oligonucleotides bear cross-linking groups, capable of causing targeted modification of the CCR-5 gene. Such modifications can impair the ability of the CCR-5 gene product to serve as a co-receptor for human immunodeficiency viruses.