发明名称 |
Cloning and expression of human islet glutamic acid decarboxylase autoantigen |
摘要 |
Human pancreatic islet cell glutamic acid decarboxylase (GAD), an autoantigen involved in the development of insulin-dependent diabetes mellitus (IDDM), has been cloned, sequenced and expressed by recombinant means. Recombinant human islet cell GAD polypeptides and antibodies specific to the GAD polypeptides can be used in methods of diagnosis and treatment, including use in immunoadsorptive therapy and the induction of immune tolerance.
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申请公布号 |
US5792620(A) |
申请公布日期 |
1998.08.11 |
申请号 |
US19930108145 |
申请日期 |
1993.08.17 |
申请人 |
THE BOARD OF REGENTS OF THE UNIVERSITY OF WASHINGTON;ZYMOGENETICS, INC. |
发明人 |
LERNMARK, AKE;KARLSEN, ALLAN E.;GRUBIN, CATHERINE E.;HAGOPIAN, WILLIAM;O'HARA, PATRICK J.;FOSTER, DONALD C. |
分类号 |
A61K38/00;A61K38/11;A61P37/00;C07K16/40;C12N1/21;C12N9/04;C12N9/88;C12N15/09;C12R1/19;G01N33/53;G01N33/573;(IPC1-7):G01N33/543 |
主分类号 |
A61K38/00 |
代理机构 |
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主权项 |
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地址 |
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