发明名称 COMPOSITIONS AND METHOD FOR THE TREATMENT OR PROPHYLAXIS OF SEPSIS OR SEPTIC SHOCK
摘要 Pharmaceutical compositions useful for the treatment or prophylaxis of Gram-negative bacteremia or septic shock contain a bactericidal effective amount of polyclonal immunoglobulins against Gram-negative bacteria and a blood clot-dissolving effective amount of protein C. The compositions may further contain one or more protein C cofactors and monoclonal antibodies against Gram-negative bacterial endotoxins. A method for the treatment or prophylaxis of Gram-negative bacteremia or septic shock comprises administering, either together or separately, a bactericidal effective amount of polyclonal immunoglobulins against Gram-negative bacteria and a blood clot-dissolving effective amount of protein C. The method may optionally include administering one or more protein C cofactors and monoclonal antibodies against Gram-negative bacterial endotoxins.
申请公布号 CA1339990(C) 申请公布日期 1998.08.11
申请号 CA19890615182 申请日期 1989.09.29
申请人 BAXTER INTERNATIONAL INC. 发明人 LAWRENCE, JOYCE E.;GRIFFITH, MICHAEL J.;ALPERN, MELAINE
分类号 A61K38/43;A61K39/395;A61K39/40;A61P9/00;A61P31/04;(IPC1-7):A61K39/40;A61K38/48 主分类号 A61K38/43
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