发明名称 |
COMPOSITIONS AND METHOD FOR THE TREATMENT OR PROPHYLAXIS OF SEPSIS OR SEPTIC SHOCK |
摘要 |
Pharmaceutical compositions useful for the treatment or prophylaxis of Gram-negative bacteremia or septic shock contain a bactericidal effective amount of polyclonal immunoglobulins against Gram-negative bacteria and a blood clot-dissolving effective amount of protein C. The compositions may further contain one or more protein C cofactors and monoclonal antibodies against Gram-negative bacterial endotoxins. A method for the treatment or prophylaxis of Gram-negative bacteremia or septic shock comprises administering, either together or separately, a bactericidal effective amount of polyclonal immunoglobulins against Gram-negative bacteria and a blood clot-dissolving effective amount of protein C. The method may optionally include administering one or more protein C cofactors and monoclonal antibodies against Gram-negative bacterial endotoxins.
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申请公布号 |
CA1339990(C) |
申请公布日期 |
1998.08.11 |
申请号 |
CA19890615182 |
申请日期 |
1989.09.29 |
申请人 |
BAXTER INTERNATIONAL INC. |
发明人 |
LAWRENCE, JOYCE E.;GRIFFITH, MICHAEL J.;ALPERN, MELAINE |
分类号 |
A61K38/43;A61K39/395;A61K39/40;A61P9/00;A61P31/04;(IPC1-7):A61K39/40;A61K38/48 |
主分类号 |
A61K38/43 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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