发明名称 |
Use of peptides for altering bone resorption |
摘要 |
The present invention provides Arg-Gly-Asp peptides that can alter the binding of osteoclasts to a matrix such as bone or can selectively alter integrin receptor binding. The invention also provides methods of using the Arg-Gly-Asp peptides to alter alpha v beta 3 integrin receptor-mediated binding of a cell such as an osteoclast, endothelial cell or smooth muscle cell to a matrix. The invention further provides methods for ameliorating the severity of a pathology characterized, in part, by an undesirable level of bone resorption, angiogenesis or restenosis in a subject.
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申请公布号 |
US5792745(A) |
申请公布日期 |
1998.08.11 |
申请号 |
US19950421697 |
申请日期 |
1995.04.12 |
申请人 |
LA JOLLA CANCER RESEARCH CENTER |
发明人 |
CHENG, SOAN;INGRAM, RONALD;MULLEN, DANIEL;TSCHOPP, JUERG F. |
分类号 |
A61K38/00;A61P3/02;A61P9/10;A61P43/00;C07K5/10;C07K7/06;C07K7/08;C07K14/75;C07K14/78;(IPC1-7):A61K38/08;A61K38/12;C07K7/54 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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