| 摘要 |
<p>PROBLEM TO BE SOLVED: To obtain the subject compound of which oxide content is decreased by adding a metal salt to form a complex thereof with trisubstituted phosphine and separating the complex formed from the mixture. SOLUTION: A reducing agent such as a trisubstituted phosphine represented by the formula (R<1> is H, a 1-6C alkyl; R<2> and R<3> are each H, a 1-6C alkyl; R<4> and R<5> are each H, a 1-6C alkyl; R<6> -R<8> are each H, a 1-6C haloalkyl) is oxidized to form the oxide. A metal salt of an alkali metal is added to the oxide in a range from 0.25-5 molar equivalent based on the oxide to effect the Mitsunobu reaction. In the reaction, the reaction mixture is kept at the temperature ranging from 0 to 120 deg.C for 16 hours at maximum, then cooled down in the temperature range from -10 deg.C - the ambient temperature to form complex. The remaining complex is separated by filtration or centrifugation to decrease the oxide.</p> |
